Specific Set of Nerve Cells Control Seizures


Specific Set of Nerve Cells Control Seizures

Epilepsy is a complex disease with diverse clinical characteristics that preclude a singular mechanism. One way to gain insight into potential mechanisms is to reduce the features of epilepsy to its basic components: seizures, epileptogenesis, and the state of recurrent unprovoked seizures that defines epilepsy itself.


The difference between seizures and epilepsy is commonly confused. The two are not the same. Epilepsy is defined by a state of recurrent, spontaneous seizures. If one seizure occurs in an individual, it may not necessarily mean that they have epilepsy because the seizure may have been provoked and that individual may never have a seizure again.
Reviewing some of the basic principles in neurobiology can provide a framework to understand the mechanisms of
  • ·         seizures
  • ·         Epileptogenesis
  • ·         epilepsy

Scientists have discovered that a little arrangement of nerve cells in the cerebrum controls the weakening seizures and psychological shortages normal for the most widely recognized type of epilepsy in grown-ups. This disclosure could prompt new and better medications.

The Test:
Test enactment of a little arrangement of nerve cells in the cerebrum forestalls convulsive seizures in a mouse model of fleeting projection epilepsy, the most well-known type of epilepsy among human, as per an investigation by scientists.
Conversely, inactivating these cells, referred to neuroscientists as overgrown cells, encourages the spread all through the cerebrum of the electrical hyperactivity at first limited at a seizure's beginning, causing the out and out behavioural manifestations of fleeting flap epilepsy.                                                   

Mossy cells:
Mossy cells are known to be damaged easily as a result of head trauma and decreased blood supply. Such brain injuries, in turn, increase the risk for temporal lobe epilepsy. The role of mossy cells in epilepsy has perplexed neuroscientists for a couple of decades.
Developing drugs that could bring therapeutic relief to people with chronic, drug-resistant epilepsy, a debilitating condition that not only circumscribes patients' lifestyles and occupational options but predisposes them to depression, anxiety and early death.

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